CLPS

GENERAL INFORMATION

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Gene name

CLPS

Gene description

Colipase, pancreatic

Protein class

Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (pancreas)
GTEx:Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in pancreas.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA010512
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (pancreas)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (pancreas)

Organ

Expression



GENE INFORMATION

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Gene name

CLPS

Synonyms

Description

Colipase, pancreatic (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a cofactor needed by pancreatic lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

6

Cytoband

p21.31

Chromosome location (bp)

35794982 - 35797344

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137392 (version 78.38)

Entrez gene

1208

UniProt

P04118 (UniProt - Evidence at protein level)

neXtProt

NX_P04118

Antibodypedia

CLPS antibodies


PROTEIN BROWSER

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ENST00000259938
 
ENST00000616014
 
ENST00000622413
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CLPS-001 ENSP00000259938
ENST00000259938
P04118
Show all »
Show » Show » 112 12 Yes 0
CLPS-201 ENSP00000483589
ENST00000616014
Q5U808
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Show » Show » 71 7.7 Yes 0
CLPS-202 ENSP00000482919
ENST00000622413
Show » Show » 98 10.6 No 0