RPLP1

GENERAL INFORMATION

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Gene name

RPLP1

Gene description

Ribosomal protein, large, P1

Protein class

Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Exocrine pancreas showed strong cytoplasmic positivity. Moderate staining was observed in stomach, a subset of renal tubules, trophoblastic cells, fallopian tube and purkinje cells. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA003368
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RPLP1 (HGNC Symbol)

Synonyms

LP1

Description

Ribosomal protein, large, P1 (HGNC Symbol)

Entrez gene summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q23

Chromosome location (bp)

69452784 - 69456194

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137818 (version 78.38)

Entrez gene

6176

UniProt

P05386 (UniProt - Evidence at protein level)

neXtProt

NX_P05386

Antibodypedia

RPLP1 antibodies


PROTEIN BROWSER

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ENST00000260379
 
ENST00000357790
 
ENST00000560274
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPLP1-001 ENSP00000346037
ENST00000260379
P05386
Show all »
Show » Show » 114 11.5 No 0
RPLP1-002 ENSP00000350437
ENST00000357790
P05386
Show all »
Show » Show » 89 8.8 No 0
RPLP1-006 ENSP00000453067
ENST00000560274
H0YL57
Show all »
Show » 54 6.4 No 0