ADAM10

GENERAL INFORMATION

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Gene name

ADAM10

Gene description

ADAM metallopeptidase domain 10

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB001709
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ADAM10 (HGNC Symbol)

Synonyms

CD156c, HsT18717, kuz, MADM

Description

ADAM metallopeptidase domain 10 (HGNC Symbol)

Entrez gene summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q21.3

Chromosome location (bp)

58588807 - 58749978

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137845 (version 78.38)

Entrez gene

102

UniProt

O14672 (UniProt - Evidence at protein level)

neXtProt

NX_O14672

Antibodypedia

ADAM10 antibodies


PROTEIN BROWSER

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ENST00000260408
 
ENST00000402627
 
ENST00000439637
 
ENST00000461408
 
ENST00000558004
 
ENST00000559053
 
ENST00000561288
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM10-001 ENSP00000260408
ENST00000260408
O14672
Show all »
Show » Show » 748 84.1 Yes 1
ADAM10-003 ENSP00000481779
ENST00000461408
Show » 59 6.4 Yes 0
ADAM10-006 ENSP00000386056
ENST00000402627
B5MC71
Show all »
Show » Show » 71 7.5 Yes 0
ADAM10-010 ENSP00000391930
ENST00000439637
C9J9B4
Show all »
Show » Show » 125 14.5 Yes 0
ADAM10-013 ENSP00000452704
ENST00000558004
H0YK87
Show all »
Show » Show » 115 13.2 Yes 0
ADAM10-016 ENSP00000453952
ENST00000559053
H0YNC5
Show all »
Show » Show » 148 16 Yes 0
ADAM10-017 ENSP00000452639
ENST00000561288
H0YK32
Show all »
Show » 38 4.1 Yes 0