CYP19A1

GENERAL INFORMATION

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Gene name

CYP19A1

Gene description

Cytochrome P450, family 19, subfamily A, polypeptide 1

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

14
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (placenta)
GTEx:Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in placental trophoblasts.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA051194 , CAB000355
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression



GENE INFORMATION

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Gene name

CYP19A1 (HGNC Symbol)

Synonyms

ARO, ARO1, aromatase, CPV1, CYAR, CYP19, P-450AROM

Description

Cytochrome P450, family 19, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

51208057 - 51338610

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137869 (version 78.38)

Entrez gene

1588

UniProt

P11511 (UniProt - Evidence at protein level)

neXtProt

NX_P11511

Antibodypedia

CYP19A1 antibodies


PROTEIN BROWSER

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ENST00000260433
 
ENST00000396402
 
ENST00000396404
 
ENST00000405011
 
ENST00000405913
 
ENST00000453807
 
ENST00000557858
 
ENST00000558328
 
ENST00000559646
 
ENST00000559653
 
ENST00000559878
 
ENST00000559980
 
ENST00000561075
 
ENST00000613097
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CYP19A1-001 ENSP00000379683
ENST00000396402
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-002 ENSP00000452872
ENST00000559980
H0YKN1
Show all »
Show » Show » 172 19.3 No 0
CYP19A1-004 ENSP00000383930
ENST00000405913
P11511
Show all »
Show » Show » 218 24.5 No 0
CYP19A1-007 ENSP00000379685
ENST00000396404
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-008 ENSP00000391139
ENST00000453807
E7EPL6
Show all »
Show » Show » 242 27.5 No 0
CYP19A1-012 ENSP00000453318
ENST00000559646
H0YLS2
Show all »
Show » Show » 165 18.5 No 0
CYP19A1-013 ENSP00000384389
ENST00000405011
E9PGZ6
Show all »
Show » Show » 166 18.6 No 0
CYP19A1-014 ENSP00000453149
ENST00000559878
P11511
Show all »
Show » Show » 503 57.9 No 1
CYP19A1-015 ENSP00000453280
ENST00000558328
H0YLP1
Show all »
Show » Show » 283 32.3 No 0
CYP19A1-016 ENSP00000452627
ENST00000557858
P11511
Show all »
Show » Show » 218 24.5 No 0
CYP19A1-017 ENSP00000454039
ENST00000561075
H0YNJ7
Show all »
Show » Show » 244 28.1 No 0
CYP19A1-020 ENSP00000452667
ENST00000559653
Show » Show » 138 15.9 No 1
CYP19A1-201 ENSP00000260433
ENST00000260433
P11511
Show all »
Show » Show » 503 57.9 No 2
CYP19A1-202 ENSP00000479587
ENST00000613097
Show » 41 4.9 No 0