BCAR3

GENERAL INFORMATION

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Gene name

BCAR3

Gene description

Breast cancer anti-estrogen resistance 3

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed weak to moderate cytoplasmic positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA014858
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BCAR3 (HGNC Symbol)

Synonyms

NSP2, SH2D3B

Description

Breast cancer anti-estrogen resistance 3 (HGNC Symbol)

Entrez gene summary

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

1

Cytoband

p22.1

Chromosome location (bp)

93561786 - 93847150

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000137936 (version 78.38)

Entrez gene

8412

UniProt

O75815 (UniProt - Evidence at protein level)

neXtProt

NX_O75815

Antibodypedia

BCAR3 antibodies


PROTEIN BROWSER

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ENST00000260502
 
ENST00000370243
 
ENST00000370244
 
ENST00000370247
 
ENST00000539242
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCAR3-001 ENSP00000260502
ENST00000260502
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-002 ENSP00000359263
ENST00000370243
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-003 ENSP00000359264
ENST00000370244
O75815
Show all »
Show » Show » 825 92.6 No 0
BCAR3-004 ENSP00000359267
ENST00000370247
O75815
Show all »
Show » Show » 734 82.4 No 0
BCAR3-201 ENSP00000441343
ENST00000539242
O75815
Show all »
Show » Show » 501 55.7 No 0