HADH

GENERAL INFORMATION

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Gene name

HADH

Gene description

Hydroxyacyl-CoA dehydrogenase

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression with a granular expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA039588
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HADH (HGNC Symbol)

Synonyms

HADH1, HADHSC, SCHAD

Description

Hydroxyacyl-CoA dehydrogenase (HGNC Symbol)

Entrez gene summary

This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

107989714 - 108035175

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138796 (version 78.38)

Entrez gene

3033

UniProt

Q16836 (UniProt - Evidence at protein level)

neXtProt

NX_Q16836

Antibodypedia

HADH antibodies


PROTEIN BROWSER

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ENST00000309522
 
ENST00000403312
 
ENST00000505878
 
ENST00000603302
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HADH-001 ENSP00000312288
ENST00000309522
Q16836
Show all »
Show » Show » 314 34.3 No 0
HADH-002 ENSP00000385638
ENST00000403312
Show » Show » 390 42.1 No 0
HADH-003 ENSP00000425952
ENST00000505878
E9PF18
Show all »
Show » Show » 318 35.2 No 0
HADH-201 ENSP00000474560
ENST00000603302
Q16836
Show all »
Show » Show » 331 36.1 No 0