ADAM21

GENERAL INFORMATION

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Gene name

ADAM21

Gene description

ADAM metallopeptidase domain 21

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in Leydig cells in testis.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA059016
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

ADAM21 (HGNC Symbol)

Synonyms

ADAM31

Description

ADAM metallopeptidase domain 21 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]

Chromosome

14

Cytoband

q24.2

Chromosome location (bp)

70452157 - 70459899

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139985 (version 78.38)

Entrez gene

8747

UniProt

Q9UKJ8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UKJ8

Antibodypedia

ADAM21 antibodies


PROTEIN BROWSER

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ENST00000603540
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM21-001 ENSP00000474385
ENST00000603540
Q9UKJ8
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Show » Show » 722 80.8 Yes 1