ASGR1

GENERAL INFORMATION

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Gene name

ASGR1

Gene description

Asialoglycoprotein receptor 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

8
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic expression in hepatocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA011954 , HPA012852
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

ASGR1 (HGNC Symbol)

Synonyms

CLEC4H1

Description

Asialoglycoprotein receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7173431 - 7179564

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141505 (version 78.38)

Entrez gene

432

UniProt

P07306 (UniProt - Evidence at protein level)

neXtProt

NX_P07306

Antibodypedia

ASGR1 antibodies


PROTEIN BROWSER

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ENST00000269299
 
ENST00000380920
 
ENST00000570576
 
ENST00000572879
 
ENST00000573083
 
ENST00000574330
 
ENST00000574388
 
ENST00000619926
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ASGR1-001 ENSP00000269299
ENST00000269299
P07306
Show all »
Show » Show » 291 33.2 No 0
ASGR1-002 ENSP00000459169
ENST00000574388
P07306
Show all »
Show » Show » 252 29.1 No 0
ASGR1-007 ENSP00000467511
ENST00000574330
I3L129
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Show » Show » 162 18.4 No 0
ASGR1-008 ENSP00000370307
ENST00000380920
J3QSZ2
Show all »
Show » Show » 190 22 No 0
ASGR1-009 ENSP00000458530
ENST00000572879
I3L129
Show all »
Show » Show » 94 10.9 No 0
ASGR1-010 ENSP00000458803
ENST00000570576
I3L1F8
Show all »
Show » 30 3.5 No 0
ASGR1-011 ENSP00000459896
ENST00000573083
I3L2S9
Show all »
Show » 117 13 No 0
ASGR1-201 ENSP00000481182
ENST00000619926
P07306
Show all »
Show » Show » 252 29.1 No 0