BCL10

GENERAL INFORMATION

? »

Gene name

BCL10

Gene description

B-cell CLL/lymphoma 10

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most cell types.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA017925 , CAB001944
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

BCL10 (HGNC Symbol)

Synonyms

c-E10, CARMEN, CIPER, CLAP, mE10

Description

B-cell CLL/lymphoma 10 (HGNC Symbol)

Entrez gene summary

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p22.3

Chromosome location (bp)

85266248 - 85277090

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000142867 (version 78.38)

Entrez gene

8915

UniProt

O95999 (UniProt - Evidence at protein level)

neXtProt

NX_O95999

Antibodypedia

BCL10 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000370580
 
ENST00000620248
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL10-001 ENSP00000359612
ENST00000370580
O95999
Show all »
Show » Show » 233 26.3 No 0
BCL10-201 ENSP00000480561
ENST00000620248
Show » Show » 156 18.1 No 0