TPM3

GENERAL INFORMATION

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Gene name

TPM3

Gene description

Tropomyosin 3

Protein class

Cancer-related genes
Cytoskeleton related proteins
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression, mainly in skeletal myocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Data reliability

Uncertain based on 4 antibodies.
HPA000261 , HPA009066 , HPA047089 , HPA053624
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (skeletal muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (skeletal muscle)

Organ

Expression



GENE INFORMATION

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Gene name

TPM3 (HGNC Symbol)

Synonyms

NEM1, TRK

Description

Tropomyosin 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Chromosome

1

Cytoband

q21.3

Chromosome location (bp)

154155304 - 154194648

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143549 (version 78.38)

Entrez gene

7170

UniProt

P06753 (UniProt - Evidence at protein level)

neXtProt

NX_P06753

Antibodypedia

TPM3 antibodies


PROTEIN BROWSER

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ENST00000271850
 
ENST00000302206
 
ENST00000323144
 
ENST00000328159
 
ENST00000330188
 
ENST00000341372
 
ENST00000341485
 
ENST00000368530
 
ENST00000368531
 
ENST00000368533
 
ENST00000515609
 
ENST00000611659
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPM3-001 ENSP00000357516
ENST00000368530
P06753
Show all »
Show » Show » 285 32.9 No 0
TPM3-003 ENSP00000341653
ENST00000341485
Q5HYB6
Show all »
Show » Show » 232 27.2 No 0
TPM3-004 ENSP00000357521
ENST00000368533
P06753
Show all »
Show » Show » 248 29 No 0
TPM3-005 ENSP00000339378
ENST00000341372
Q5VU61
Show all »
Show » 223 26.1 No 0
TPM3-006 ENSP00000357520
ENST00000328159
P06753
Show all »
Show » Show » 248 28.9 No 0
TPM3-009 ENSP00000339035
ENST00000330188
P06753
Show all »
Show » Show » 248 28.9 No 0
TPM3-010 ENSP00000357518
ENST00000323144
P06753
Show all »
Show » Show » 247 28.8 No 0
TPM3-011 ENSP00000307712
ENST00000302206
P06753
Show all »
Show » Show » 158 18.6 No 0
TPM3-015 ENSP00000271850
ENST00000271850
J3KN67
Show all »
Show » 285 33.2 No 0
TPM3-018 ENSP00000426306
ENST00000515609
D6RGJ6
Show all »
Show » 75 8.7 No 0
TPM3-026 ENSP00000357517
ENST00000368531
P06753
Show all »
Show » Show » 247 29 No 0
TPM3-201 ENSP00000480520
ENST00000611659
Show » Show » 227 26.4 No 0