PYCR2

GENERAL INFORMATION

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Gene name

PYCR2

Gene description

Pyrroline-5-carboxylate reductase family, member 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Oral mucosa, rectum, seminal vesicle, fibroblasts and Leydig cells displayed strong cytoplasmic staining in granular pattern. Hematopoietic cells, respiratory epithelia, colon, esophagus, exocrine pancreas, prostate, stomach, vaginal epithelium and urothelium were moderately positive. Remaining normal tissues were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA056873
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PYCR2 (HGNC Symbol)

Synonyms

P5CR2

Description

Pyrroline-5-carboxylate reductase family, member 2 (HGNC Symbol)

Entrez gene summary

This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

Chromosome

1

Cytoband

q42.12

Chromosome location (bp)

225919877 - 225924340

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000143811 (version 78.38)

Entrez gene

29920

UniProt

Q96C36 (UniProt - Evidence at protein level)

neXtProt

NX_Q96C36

Antibodypedia

PYCR2 antibodies


PROTEIN BROWSER

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ENST00000343818
 
ENST00000472798
 
ENST00000489681
 
ENST00000612039
 
ENST00000612651
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PYCR2-001 ENSP00000342502
ENST00000343818
Q96C36
Show all »
Show » Show » 320 33.6 No 0
PYCR2-006 ENSP00000482614
ENST00000489681
Show » Show » 157 16.6 No 0
PYCR2-007 ENSP00000480779
ENST00000472798
Show » Show » 87 9.5 No 0
PYCR2-201 ENSP00000478165
ENST00000612039
Show » Show » 246 25.9 No 0
PYCR2-202 ENSP00000482845
ENST00000612651
B3KMB7
Show all »
Show » Show » 319 33.6 No 0