ECE2

GENERAL INFORMATION

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Gene name

ECE2

Gene description

Endothelin converting enzyme 2

Protein class

Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Parts of the gastrointestinal tract, gall bladder, adrenal gland, glial cells and renal tubules displayed strong cytoplasmic and nuclear staining. Squamous epithelia, hepatocytes, respiratory epithelia, prostate, thyroid and Leydig cells were moderately stained. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA043346
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

ECE2 (HGNC Symbol)

Synonyms

KIAA0604, MGC2408

Description

Endothelin converting enzyme 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

184249650 - 184293031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145194 (version 78.38)

Entrez gene

9718

UniProt

O60344 (UniProt - Evidence at protein level)

neXtProt

NX_O60344

Antibodypedia

ECE2 antibodies


PROTEIN BROWSER

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ENST00000324557
 
ENST00000357474
 
ENST00000359140
 
ENST00000402825
 
ENST00000404464
 
ENST00000430587
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ECE2-001 ENSP00000384223
ENST00000402825
O60344
Show all »
Show » Show » 883 99.8 No 1
ECE2-002 ENSP00000314295
ENST00000324557
O60344
Show all »
Show » Show » 255 28.3 No 0
ECE2-003 ENSP00000385846
ENST00000404464
O60344
Show all »
Show » Show » 765 86.5 No 1
ECE2-004 ENSP00000352052
ENST00000359140
O60344
Show all »
Show » Show » 736 83.3 No 1
ECE2-006 ENSP00000350066
ENST00000357474
O60344
Show all »
Show » Show » 811 91.2 No 1
ECE2-007 ENSP00000398444
ENST00000430587
H0Y5G8
Show all »
Show » Show » 716 81 No 1