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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
4
Cytoband
q31.3
Chromosome location (bp)
153780591 - 153789083
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation, Wnt signaling pathway
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Q96HF1 [Direct mapping] Secreted frizzled-related protein 2
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A0A140VJU3 [Target identity:100%; Query identity:100%] Testicular tissue protein Li 170
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THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001569[branching involved in blood vessel morphogenesis] GO:0001756[somitogenesis] GO:0001843[neural tube closure] GO:0001968[fibronectin binding] GO:0002063[chondrocyte development] GO:0003151[outflow tract morphogenesis] GO:0003214[cardiac left ventricle morphogenesis] GO:0003402[planar cell polarity pathway involved in axis elongation] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0006915[apoptotic process] GO:0007267[cell-cell signaling] GO:0007501[mesodermal cell fate specification] GO:0007584[response to nutrient] GO:0008047[enzyme activator activity] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008584[male gonad development] GO:0009410[response to xenobiotic stimulus] GO:0009952[anterior/posterior pattern specification] GO:0010629[negative regulation of gene expression] GO:0010659[cardiac muscle cell apoptotic process] GO:0010667[negative regulation of cardiac muscle cell apoptotic process] GO:0010719[negative regulation of epithelial to mesenchymal transition] GO:0010950[positive regulation of endopeptidase activity] GO:0010975[regulation of neuron projection development] GO:0016055[Wnt signaling pathway] GO:0017147[Wnt-protein binding] GO:0021915[neural tube development] GO:0030111[regulation of Wnt signaling pathway] GO:0030154[cell differentiation] GO:0030178[negative regulation of Wnt signaling pathway] GO:0030199[collagen fibril organization] GO:0030307[positive regulation of cell growth] GO:0030308[negative regulation of cell growth] GO:0030336[negative regulation of cell migration] GO:0030509[BMP signaling pathway] GO:0030514[negative regulation of BMP signaling pathway] GO:0031668[cellular response to extracellular stimulus] GO:0033138[positive regulation of peptidyl-serine phosphorylation] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0036342[post-anal tail morphogenesis] GO:0042127[regulation of cell population proliferation] GO:0042662[negative regulation of mesodermal cell fate specification] GO:0042733[embryonic digit morphogenesis] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043154[negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043508[negative regulation of JUN kinase activity] GO:0045600[positive regulation of fat cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045766[positive regulation of angiogenesis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046546[development of primary male sexual characteristics] GO:0048018[receptor ligand activity] GO:0048546[digestive tract morphogenesis] GO:0048856[anatomical structure development] GO:0048866[stem cell fate specification] GO:0050680[negative regulation of epithelial cell proliferation] GO:0050732[negative regulation of peptidyl-tyrosine phosphorylation] GO:0050793[regulation of developmental process] GO:0051216[cartilage development] GO:0060028[convergent extension involved in axis elongation] GO:0060070[canonical Wnt signaling pathway] GO:0061056[sclerotome development] GO:0061133[endopeptidase activator activity] GO:0061185[negative regulation of dermatome development] GO:0062023[collagen-containing extracellular matrix] GO:0071425[hematopoietic stem cell proliferation] GO:0071481[cellular response to X-ray] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090175[regulation of establishment of planar polarity] GO:0090179[planar cell polarity pathway involved in neural tube closure] GO:0090244[Wnt signaling pathway involved in somitogenesis] GO:0090263[positive regulation of canonical Wnt signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1904956[regulation of midbrain dopaminergic neuron differentiation] GO:2000035[regulation of stem cell division] GO:2000041[negative regulation of planar cell polarity pathway involved in axis elongation]