NKD2

GENERAL INFORMATION

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Gene name

NKD2

Gene description

Naked cuticle homolog 2 (Drosophila)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein localization

Stomach, nasopharynx, subset of renal tubules, salivary gland, hepatocytes and placenta displayed strong cytoplasmic positivity. Breast, colon, heart muscle, prostate, rectum and glandular cells of uterus were moderately stained. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA049463
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (lung)

Organ

Expression



GENE INFORMATION

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Gene name

NKD2 (HGNC Symbol)

Synonyms

Naked2

Description

Naked cuticle homolog 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1008829 - 1038943

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145506 (version 78.38)

Entrez gene

85409

UniProt

Q969F2 (UniProt - Evidence at protein level)

neXtProt

NX_Q969F2

Antibodypedia

NKD2 antibodies


PROTEIN BROWSER

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ENST00000274150
 
ENST00000296849
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NKD2-001 ENSP00000296849
ENST00000296849
Q969F2
Show all »
Show » Show » 451 50.1 No 0
NKD2-002 ENSP00000274150
ENST00000274150
Q969F2
Show all »
Show » Show » 311 34.3 No 0