SRD5A1

GENERAL INFORMATION

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Gene name

SRD5A1

Gene description

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic staining with a granular pattern was observed in prostate as well as several other normal tissues although the staining was not as prominent. Squamous epithelia, bile ducts, exocrine pancreas, placental trophoblastic cells, glial cells, lymphoid tissue and muscle were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA051402
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SRD5A1

Synonyms

Description

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (HGNC Symbol)

Entrez gene summary

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

Chromosome

5

Cytoband

p15.31

Chromosome location (bp)

6633343 - 6669562

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145545 (version 78.38)

Entrez gene

6715

UniProt

P18405 (UniProt - Evidence at protein level)

neXtProt

NX_P18405

Antibodypedia

SRD5A1 antibodies


PROTEIN BROWSER

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ENST00000274192
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRD5A1-001 ENSP00000274192
ENST00000274192
P18405
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