GZMA

GENERAL INFORMATION

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Gene name

GZMA

Gene description

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
HPA054134
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

GZMA (HGNC Symbol)

Synonyms

CTLA3, HFSP

Description

Granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) (HGNC Symbol)

Entrez gene summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

55102648 - 55110252

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145649 (version 78.38)

Entrez gene

3001

UniProt

P12544 (UniProt - Evidence at protein level)

neXtProt

NX_P12544

Antibodypedia

GZMA antibodies


PROTEIN BROWSER

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ENST00000274306
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GZMA-001 ENSP00000274306
ENST00000274306
P12544
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