DOK2

GENERAL INFORMATION

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Gene name

DOK2

Gene description

Docking protein 2, 56kDa

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic and nuclear expression in lymphoid cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 1 antibody.
CAB004379
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

DOK2 (HGNC Symbol)

Synonyms

Dok-2, p56dok-2

Description

Docking protein 2, 56kDa (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p21.3

Chromosome location (bp)

21908873 - 21913860

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147443 (version 78.38)

Entrez gene

9046

UniProt

O60496 (UniProt - Evidence at protein level)

neXtProt

NX_O60496

Antibodypedia

DOK2 antibodies


PROTEIN BROWSER

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ENST00000276420
 
ENST00000518197
 
ENST00000523932
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DOK2-001 ENSP00000276420
ENST00000276420
O60496
Show all »
Show » Show » 412 45.4 No 0
DOK2-004 ENSP00000429224
ENST00000523932
E5RJ11
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Show » Show » 233 26 No 0
DOK2-007 ENSP00000430729
ENST00000518197
E5RIG9
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Show » Show » 151 16.7 No 0