UHRF2

GENERAL INFORMATION

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Gene name

UHRF2

Gene description

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic and occasional nuclear expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA026633 , HPA026697
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UHRF2 (HGNC Symbol)

Synonyms

MGC33463, NIRF, RNF107, URF2

Description

Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

Chromosome

9

Cytoband

p24.1

Chromosome location (bp)

6413151 - 6507054

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147854 (version 78.38)

Entrez gene

115426

UniProt

Q96PU4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96PU4

Antibodypedia

UHRF2 antibodies


PROTEIN BROWSER

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ENST00000276893
 
ENST00000381373
 
ENST00000450508
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UHRF2-002 ENSP00000370778
ENST00000381373
B1AL33
Show all »
Show » Show » 136 15.3 No 0
UHRF2-003 ENSP00000276893
ENST00000276893
Q96PU4
Show all »
Show » Show » 802 90 No 0
UHRF2-004 ENSP00000399217
ENST00000450508
Show » 112 12.7 No 0