PTGES

GENERAL INFORMATION

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Gene name

PTGES

Gene description

Prostaglandin E synthase

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues, most prominent in seminal vesicle, placenta and urinary bladder.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA045064
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

PTGES (HGNC Symbol)

Synonyms

MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12

Description

Prostaglandin E synthase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

129738331 - 129753047

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148344 (version 78.38)

Entrez gene

9536

UniProt

O14684 (UniProt - Evidence at protein level)

neXtProt

NX_O14684

Antibodypedia

PTGES antibodies


PROTEIN BROWSER

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ENST00000340607
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTGES-001 ENSP00000342385
ENST00000340607
O14684
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