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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
p15.4
Chromosome location (bp)
10305073 - 10307397
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hormone
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001570[vasculogenesis] GO:0001666[response to hypoxia] GO:0001843[neural tube closure] GO:0002026[regulation of the force of heart contraction] GO:0002031[G protein-coupled receptor internalization] GO:0003073[regulation of systemic arterial blood pressure] GO:0005102[signaling receptor binding] GO:0005179[hormone activity] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005737[cytoplasm] GO:0006954[inflammatory response] GO:0007165[signal transduction] GO:0007189[adenylate cyclase-activating G protein-coupled receptor signaling pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007507[heart development] GO:0007565[female pregnancy] GO:0007568[aging] GO:0008209[androgen metabolic process] GO:0008283[cell population proliferation] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009409[response to cold] GO:0009611[response to wounding] GO:0010033[response to organic substance] GO:0010460[positive regulation of heart rate] GO:0019933[cAMP-mediated signaling] GO:0031100[animal organ regeneration] GO:0031102[neuron projection regeneration] GO:0031623[receptor internalization] GO:0031700[adrenomedullin receptor binding] GO:0032496[response to lipopolysaccharide] GO:0032868[response to insulin] GO:0035809[regulation of urine volume] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042594[response to starvation] GO:0043065[positive regulation of apoptotic process] GO:0043116[negative regulation of vascular permeability] GO:0045766[positive regulation of angiogenesis] GO:0045906[negative regulation of vasoconstriction] GO:0046879[hormone secretion] GO:0048589[developmental growth] GO:0051384[response to glucocorticoid] GO:0055074[calcium ion homeostasis] GO:0060670[branching involved in labyrinthine layer morphogenesis] GO:0060712[spongiotrophoblast layer development] GO:0097084[vascular associated smooth muscle cell development] GO:0097647[amylin receptor signaling pathway] GO:1990410[adrenomedullin receptor signaling pathway] GO:2000184[positive regulation of progesterone biosynthetic process] GO:2001214[positive regulation of vasculogenesis]