The cancer tissue page shows antibody staining in 20 different cancers. The overall cancer tissue staining statistics shows the fraction of patient samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right), using all the available antibodies to the protein targets encoded by this gene. The assay and annotation is described here.
The cancers can be ordered histologically or alphabetically.
For each cancer, the staining for each available antibody is reported as the fraction of samples with strong, moderate, weak or no staining (as described by the color-coding scale in the box to the right). The lenght of the bar represents the number of patient samples analysed (max=12 patients). By clicking on a cancer tissue, the detailed staining data for that cancer is available, including annotated images.
At the bottom of this page, a summary for the cancer staining for each antibody is given, together with the immunohistochemistry validation score for that antibody.
Most malignancies showed moderate to strong cytoplasmic and/or nuclear positivity. Ovarian, endometrial, gastric showed weak positivity or were negative.
Most malignant cells showed weak to moderate nuclear and cytoplasmic immunoreactivity.
Cancer tissues displayed weak to moderate nuclear positivity with additional cytoplasmic staining in a few tissues. Rare case of urothelial cancer was strongly stained. Several cases of malignant lymphomas, malignant gliomas, testicular, endometrial, colorectal and pancreatic cancers were negative.
Malignant tissues showed moderate to strong nuclear and cytoplasmic staining.
Validation
Two (or more) antibodies yielding similar staining patterns which are consistent with available gene/protein characterization data
One antibody yielding a staining pattern which is consistent with gene/protein characterization data
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for all of the genes
The multi-targeting antibody yielding a staining pattern consistent with gene/protein characterization data for all of the genes
