CENPJ

GENERAL INFORMATION

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Gene name

CENPJ

Gene description

Centromere protein J

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY RELIABILITY

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Data reliability

Pending normal tissue annotation.
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A


PROTEIN EXPRESSION OVERVIEW

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Pending normal tissue annotation.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CENPJ (HGNC Symbol)

Synonyms

BM032, CPAP, LAP, LIP1, MCPH6, Sas-4, SASS4, SCKL4

Description

Centromere protein J (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

13

Cytoband

Chromosome location (bp)

24882284 - 24922889

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151849 (version 78.38)

Entrez gene

55835

UniProt

Q9HC77 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HC77

Antibodypedia

CENPJ antibodies


PROTEIN BROWSER

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ENST00000381884
 
ENST00000418179
 
ENST00000545981
 
ENST00000616936
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CENPJ-001 ENSP00000371308
ENST00000381884
Q9HC77
Show all »
Show » Show » 1338 153 No 0
CENPJ-002 ENSP00000399334
ENST00000418179
Show » 196 23.5 No 0
CENPJ-201 ENSP00000441090
ENST00000545981
Show » 1136 129.9 No 0
CENPJ-202 ENSP00000477511
ENST00000616936
Q5JPD5
Show all »
Show » 1086 124.2 No 0