PTPRD

GENERAL INFORMATION

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Gene name

PTPRD

Gene description

Protein tyrosine phosphatase, receptor type, D

Protein class

Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

11
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in glandular cells with varying intensity.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA054829
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

PTPRD (HGNC Symbol)

Synonyms

HPTP, PTPD

Description

Protein tyrosine phosphatase, receptor type, D (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

Chromosome

9

Cytoband

Chromosome location (bp)

8314246 - 10612723

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153707 (version 78.38)

Entrez gene

5789

UniProt

P23468 (UniProt - Evidence at protein level)

neXtProt

NX_P23468

Antibodypedia

PTPRD antibodies


PROTEIN BROWSER

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ENST00000355233
 
ENST00000356435
 
ENST00000381196
 
ENST00000397606
 
ENST00000397611
 
ENST00000397617
 
ENST00000463477
 
ENST00000481079
 
ENST00000486161
 
ENST00000537002
 
ENST00000540109
 
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PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTPRD-001 ENSP00000417661
ENST00000463477
C9J8S8
Show all »
Show » Show » 202 22.4 Yes 0
PTPRD-002 ENSP00000370593
ENST00000381196
P23468
Show all »
Show » Show » 1912 214.8 Yes 1
PTPRD-003 ENSP00000417093
ENST00000486161
P23468
Show all »
Show » Show » 1505 169.6 Yes 1
PTPRD-006 ENSP00000380731
ENST00000397606
P23468
Show all »
Show » Show » 1505 169.5 Yes 1
PTPRD-008 ENSP00000417890
ENST00000481079
C9J6E4
Show all »
Show » Show » 93 10.4 Yes 0
PTPRD-201 ENSP00000347373
ENST00000355233
P23468
Show all »
Show » Show » 1506 169.7 Yes 1
PTPRD-202 ENSP00000348812
ENST00000356435
P23468
Show all »
Show » Show » 1912 214.8 Yes 1
PTPRD-203 ENSP00000380735
ENST00000397611
P23468
Show all »
Show » Show » 1502 169.3 Yes 1
PTPRD-204 ENSP00000380741
ENST00000397617
F5GWR7
Show all »
Show » Show » 1505 169.4 Yes 1
PTPRD-205 ENSP00000440515
ENST00000537002
Q3KPI9
Show all »
Show » Show » 1496 168.7 Yes 1
PTPRD-206 ENSP00000438164
ENST00000540109
P23468
Show all »
Show » Show » 1912 214.8 Yes 1