MMP16

GENERAL INFORMATION

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Gene name

MMP16

Gene description

Matrix metallopeptidase 16 (membrane-inserted)

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

A majority of normal cells displayed weak to moderate cytoplasmic positivity. Strong staining was observed in placental trophoblasts and smooth muscle cells. The liver, pancreas and lymphoid cells were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA023693
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

MMP16 (HGNC Symbol)

Synonyms

C8orf57, DKFZp761D112, MT3-MMP

Description

Matrix metallopeptidase 16 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Chromosome

8

Cytoband

q21.3

Chromosome location (bp)

88032009 - 88328025

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156103 (version 78.38)

Entrez gene

4325

UniProt

P51512 (UniProt - Evidence at protein level)

neXtProt

NX_P51512

Antibodypedia

MMP16 antibodies


PROTEIN BROWSER

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ENST00000286614
 
ENST00000522726
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP16-001 ENSP00000286614
ENST00000286614
P51512
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Show » Show » 607 69.5 Yes 1
MMP16-004 ENSP00000429147
ENST00000522726
E5RJA7
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Show » Show » 168 19.5 No 0