NTAN1

GENERAL INFORMATION

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Gene name

NTAN1

Gene description

N-terminal asparagine amidase

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Extracellular staining in a few tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA051418 , CAB029997
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NTAN1

Synonyms

Description

N-terminal asparagine amidase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Chromosome

16

Cytoband

p13.11

Chromosome location (bp)

15037853 - 15056079

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157045 (version 78.38)

Entrez gene

123803

UniProt

Q96AB6 (UniProt - Evidence at protein level)

neXtProt

NX_Q96AB6

Antibodypedia

NTAN1 antibodies


PROTEIN BROWSER

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ENST00000287706
 
ENST00000566419
 
ENST00000568320
 
ENST00000622833
 
ENST00000624579
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NTAN1-001 ENSP00000287706
ENST00000287706
Q96AB6
Show all »
Show » Show » 310 34.7 No 0
NTAN1-006 ENSP00000455396
ENST00000568320
H3BPN7
Show all »
Show » Show » 146 16.8 No 0
NTAN1-007 ENSP00000454883
ENST00000566419
H3BNJ5
Show all »
Show » Show » 223 25.1 No 0
NTAN1-201 ENSP00000483643
ENST00000622833
H3BPN7
Show all »
Show » Show » 205 23.4 No 0
NTAN1-202 ENSP00000485340
ENST00000624579
H3BPN7
Show all »
Show » Show » 205 23.4 No 0