ATP2B2

GENERAL INFORMATION

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Gene name

ATP2B2

Gene description

ATPase, Ca++ transporting, plasma membrane 2

Protein class

Enzymes
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (cerebral cortex, salivary gland)
GTEx:Tissue enhanced (cerebellum, cerebral cortex)

Protein evidence

Evidence at protein level

Protein localization

High cytoplasmic expression in CNS. Cytoplasmic expression in salivary gland as well.

ANTIBODY RELIABILITY

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Data reliability
description

Presumed off target binding observed and disregarded.

Data reliability

Supportive based on 1 antibody.
CAB005606
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (cerebral cortex, salivary gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, cerebral cortex)

Organ

Expression



GENE INFORMATION

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Gene name

ATP2B2 (HGNC Symbol)

Synonyms

PMCA2

Description

ATPase, Ca++ transporting, plasma membrane 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p25.3

Chromosome location (bp)

10324023 - 10708031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157087 (version 78.38)

Entrez gene

491

UniProt

Q01814 (UniProt - Evidence at protein level)

neXtProt

NX_Q01814

Antibodypedia

ATP2B2 antibodies


PROTEIN BROWSER

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ENST00000352432
 
ENST00000360273
 
ENST00000383800
 
ENST00000397077
 
ENST00000452124
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B2-001 ENSP00000324172
ENST00000352432
Q01814
Show all »
Show » Show » 1243 136.9 No >9
ATP2B2-002 ENSP00000373311
ENST00000383800
Q01814
Show all »
Show » Show » 1198 132.6 No >9
ATP2B2-003 ENSP00000414854
ENST00000452124
H0Y7S3
Show all »
Show » Show » 1099 121.3 No 9
ATP2B2-005 ENSP00000380267
ENST00000397077
Q01814
Show all »
Show » Show » 1198 132.6 No >9
ATP2B2-201 ENSP00000353414
ENST00000360273
Q01814
Show all »
Show » Show » 1243 136.9 No >9