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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q31.2
Chromosome location (bp)
138285269 - 138338355
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005758[mitochondrial intermembrane space] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0007283[spermatogenesis] GO:0008283[cell population proliferation] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019901[protein kinase binding] GO:0048471[perinuclear region of cytoplasm] GO:0050699[WW domain binding] GO:0051301[cell division] GO:0110032[positive regulation of G2/MI transition of meiotic cell cycle] GO:1902751[positive regulation of cell cycle G2/M phase transition]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0008283[cell population proliferation] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019901[protein kinase binding] GO:0050699[WW domain binding] GO:0051301[cell division] GO:0110032[positive regulation of G2/MI transition of meiotic cell cycle] GO:1902751[positive regulation of cell cycle G2/M phase transition]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0008283[cell population proliferation] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019901[protein kinase binding] GO:0050699[WW domain binding] GO:0051301[cell division] GO:0110032[positive regulation of G2/MI transition of meiotic cell cycle] GO:1902751[positive regulation of cell cycle G2/M phase transition]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000086[G2/M transition of mitotic cell cycle] GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006470[protein dephosphorylation] GO:0007049[cell cycle] GO:0007088[regulation of mitotic nuclear division] GO:0008283[cell population proliferation] GO:0010971[positive regulation of G2/M transition of mitotic cell cycle] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019901[protein kinase binding] GO:0050699[WW domain binding] GO:0051301[cell division] GO:0110032[positive regulation of G2/MI transition of meiotic cell cycle] GO:1902751[positive regulation of cell cycle G2/M phase transition]