NCF1

GENERAL INFORMATION

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Gene name

NCF1

Gene description

Neutrophil cytosolic factor 1

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow, lymph node, spleen)
GTEx:Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in a subset of leukocytes.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA047836 , HPA052095 , CAB004524
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow, lymph node, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (spleen)

Organ

Expression



GENE INFORMATION

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Gene name

NCF1 (HGNC Symbol)

Synonyms

NCF1A, NOXO2, p47phox, SH3PXD1A

Description

Neutrophil cytosolic factor 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q11.23

Chromosome location (bp)

74773962 - 74789315

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158517 (version 78.38)

Entrez gene

653361

UniProt

P14598 (UniProt - Evidence at protein level)

neXtProt

NX_P14598

Antibodypedia

NCF1 antibodies


PROTEIN BROWSER

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ENST00000289473
 
ENST00000433458
 
ENST00000442021
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NCF1-001 ENSP00000289473
ENST00000289473
P14598
Show all »
Show » Show » 390 44.7 No 0
NCF1-011 ENSP00000401935
ENST00000442021
Show » Show » 146 17.1 No 0
NCF1-014 ENSP00000392870
ENST00000433458
Show » Show » 163 19.3 No 0