MRPL10

GENERAL INFORMATION

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Gene name

MRPL10

Gene description

Mitochondrial ribosomal protein L10

Protein class

Mitochondrial proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA021234 , HPA029885
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Ovary



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MRPL10 (HGNC Symbol)

Synonyms

L10MT, MGC17973, MRP-L10, MRP-L8, MRPL8, RPML8

Description

Mitochondrial ribosomal protein L10 (HGNC Symbol)

Entrez gene summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Nov 2010]

Chromosome

17

Cytoband

q21.32

Chromosome location (bp)

47823272 - 47831534

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159111 (version 78.38)

Entrez gene

124995

UniProt

Q7Z7H8 (UniProt - Evidence at protein level)

neXtProt

NX_Q7Z7H8

Antibodypedia

MRPL10 antibodies


PROTEIN BROWSER

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ENST00000290208
 
ENST00000351111
 
ENST00000414011
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MRPL10-001 ENSP00000324100
ENST00000351111
Q7Z7H8
Show all »
Show » Show » 261 29.3 No 0
MRPL10-002 ENSP00000395870
ENST00000414011
Q7Z7H8
Show all »
Show » Show » 271 30.3 No 0
MRPL10-003 ENSP00000290208
ENST00000290208
Q7Z7H8
Show all »
Show » Show » 271 30.3 No 0