LSS

GENERAL INFORMATION

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Gene name

LSS

Gene description

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General granular cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA032060 , HPA032062 , CAB034116
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

LSS (HGNC Symbol)

Synonyms

OSC

Description

Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

46188141 - 46228824

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160285 (version 78.38)

Entrez gene

4047

UniProt

P48449 (UniProt - Evidence at protein level)

neXtProt

NX_P48449

Antibodypedia

LSS antibodies


PROTEIN BROWSER

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ENST00000356396
 
ENST00000397728
 
ENST00000419093
 
ENST00000450351
 
ENST00000457828
 
ENST00000522411
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LSS-001 ENSP00000380837
ENST00000397728
P48449
Show all »
Show » Show » 732 83.3 No 0
LSS-002 ENSP00000348762
ENST00000356396
P48449
Show all »
Show » Show » 732 83.3 No 0
LSS-005 ENSP00000391368
ENST00000450351
C9J315
Show all »
Show » Show » 262 29.6 No 0
LSS-008 ENSP00000410678
ENST00000419093
Show » 136 15.3 No 0
LSS-010 ENSP00000429133
ENST00000522411
P48449
Show all »
Show » Show » 721 82.2 No 0
LSS-201 ENSP00000409191
ENST00000457828
P48449
Show all »
Show » Show » 652 74.2 No 0