The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Strong cytoplasmic positivity was observed in heart and skeletal muscle cells. The remaining normal tissues were generally negative.
Cardiac myocytes, smooth muscle and myoepithelial in breast showed moderate cytoplasmic staining. Gastrointestinal tract showed weak luminal membranous immunoreactivity. A subset of neuronal cells exhibited moderate nuclear positivity. Remaining normal tissues were negative.
Cytoplasmic and membranous positivity of varying intensity was observed in most normal tissues. Strongest staining was observed in muscle tissues, lymphoid tissue and digestive tract. Liver and CNS was negative.
Most of the normal tissues were negative. Smooth muscle cells, cardiomyocytes and skeletal muscle exhibited strong cytoplasmic immunoreactivity. Megakaryocytes of bone marrow and renal glomeruli were distinctly stained.