MPP3

GENERAL INFORMATION

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Gene name

MPP3

Gene description

Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Selective cytoplasmic expression in gastrointestinal tract, renal tubules and in squamous epithelia. Most abundant in gastrointestinal tract. Weak expression in a few other tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA021818 , HPA024742
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

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Gene name

MPP3 (HGNC Symbol)

Synonyms

DLG3

Description

Membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (HGNC Symbol)

Entrez gene summary

This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q21.31

Chromosome location (bp)

43800799 - 43833170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161647 (version 78.38)

Entrez gene

4356

UniProt

Q13368 (UniProt - Evidence at protein level)

neXtProt

NX_Q13368

Antibodypedia

MPP3 antibodies


PROTEIN BROWSER

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ENST00000398389
 
ENST00000398393
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MPP3-001 ENSP00000381425
ENST00000398389
Q13368
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Show » Show » 585 66.2 No 0
MPP3-002 ENSP00000381430
ENST00000398393
D3DX46
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Show » Show » 610 68.9 No 0