LMX1A

GENERAL INFORMATION

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Gene name

LMX1A

Gene description

LIM homeobox transcription factor 1, alpha

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (duodenum, testis)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at transcript level

Protein localization

Ubiquitous cytoplasmic expression in all tissues at variable levels.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA028051 , HPA030088
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (duodenum, testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

LMX1A (HGNC Symbol)

Synonyms

LMX1, LMX1.1

Description

LIM homeobox transcription factor 1, alpha (HGNC Symbol)

Entrez gene summary

This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Chromosome

1

Cytoband

q23.3

Chromosome location (bp)

165201867 - 165356715

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000162761 (version 78.38)

Entrez gene

4009

UniProt

Q8TE12 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8TE12

Antibodypedia

LMX1A antibodies


PROTEIN BROWSER

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ENST00000294816
 
ENST00000342310
 
ENST00000367893
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LMX1A-001 ENSP00000340226
ENST00000342310
Q8TE12
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Show » Show » 382 42.7 No 0
LMX1A-002 ENSP00000294816
ENST00000294816
Q8TE12
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Show » Show » 382 42.7 No 0
LMX1A-003 ENSP00000356868
ENST00000367893
Q8TE12
Show all »
Show » Show » 382 42.7 No 0