MAPKAPK2

GENERAL INFORMATION

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Gene name

MAPKAPK2

Gene description

Mitogen-activated protein kinase-activated protein kinase 2

Protein class

Cancer-related genes
Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate cytoplasmic and membranous positivity. Strong staining was observed in the gastrointestinal tract, gall bladder and endometrium. Lymphoid tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB010297
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MAPKAPK2

Synonyms

Description

Mitogen-activated protein kinase-activated protein kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

206684944 - 206734283

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162889 (version 78.38)

Entrez gene

9261

UniProt

P49137 (UniProt - Evidence at protein level)

neXtProt

NX_P49137

Antibodypedia

MAPKAPK2 antibodies


PROTEIN BROWSER

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ENST00000294981
 
ENST00000367103
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAPKAPK2-001 ENSP00000356070
ENST00000367103
P49137
Show all »
Show » Show » 400 45.6 No 1
MAPKAPK2-002 ENSP00000294981
ENST00000294981
P49137
Show all »
Show » Show » 370 42.2 No 1