DUSP19

GENERAL INFORMATION

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Gene name

DUSP19

Gene description

Dual specificity phosphatase 19

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Most normal cells were weakly stained or negative. The gastrointestinal tract, urinary bladder and renal tubules showed strong nuclear staining.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA021501
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

DUSP19 (HGNC Symbol)

Synonyms

DUSP17, SKRP1

Description

Dual specificity phosphatase 19 (HGNC Symbol)

Entrez gene summary

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

Chromosome

2

Cytoband

q32.1

Chromosome location (bp)

183078559 - 183100005

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162999 (version 78.38)

Entrez gene

142679

UniProt

Q8WTR2 (UniProt - Evidence at protein level)

neXtProt

NX_Q8WTR2

Antibodypedia

DUSP19 antibodies


PROTEIN BROWSER

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ENST00000342619
 
ENST00000354221
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DUSP19-001 ENSP00000346160
ENST00000354221
Q8WTR2
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Show » Show » 217 24.2 No 0
DUSP19-002 ENSP00000343905
ENST00000342619
Q8WTR2
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Show » Show » 166 18.3 No 0