EN1

GENERAL INFORMATION

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Gene name

EN1

Gene description

Engrailed homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adipose tissue, lymph node, skeletal muscle, skin)
GTEx:Tissue enhanced (skeletal muscle, skin)

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear positivity. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB014884
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adipose tissue, lymph node, skeletal muscle, skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skeletal muscle, skin)

Organ

Expression



GENE INFORMATION

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Gene name

EN1

Synonyms

Description

Engrailed homeobox 1 (HGNC Symbol)

Entrez gene summary

Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q14.2

Chromosome location (bp)

118842171 - 118847678

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000163064 (version 78.38)

Entrez gene

2019

UniProt

Q05925 (UniProt - Evidence at protein level)

neXtProt

NX_Q05925

Antibodypedia

EN1 antibodies


PROTEIN BROWSER

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ENST00000295206
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EN1-001 ENSP00000295206
ENST00000295206
Q05925
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