CASP7

GENERAL INFORMATION

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Gene name

CASP7

Gene description

Caspase 7, apoptosis-related cysteine peptidase

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate cytoplasmic and nuclear positivity. Strong staining was observed in the gastrointestinal tract, trophoblastic cells and Purkinje cells. The thyroid, muscle cells, spleen and most cells in CNS were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB025563
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CASP7 (HGNC Symbol)

Synonyms

CMH-1, ICE-LAP3, MCH3

Description

Caspase 7, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

10

Cytoband

q25.3

Chromosome location (bp)

113679162 - 113730907

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165806 (version 78.38)

Entrez gene

840

UniProt

P55210 (UniProt - Evidence at protein level)

neXtProt

NX_P55210

Antibodypedia

CASP7 antibodies


PROTEIN BROWSER

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ENST00000345633
 
ENST00000369315
 
ENST00000369318
 
ENST00000369321
 
ENST00000369331
 
ENST00000429617
 
ENST00000452490
 
ENST00000614447
 
ENST00000621345
 
ENST00000621607
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CASP7-001 ENSP00000358324
ENST00000369318
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-002 ENSP00000358321
ENST00000369315
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-003 ENSP00000358337
ENST00000369331
P55210
Show all »
Show » Show » 253 28 No 0
CASP7-004 ENSP00000400094
ENST00000429617
Q5SVL2
Show all »
Show » Show » 222 24.8 No 0
CASP7-005 ENSP00000298701
ENST00000345633
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-201 ENSP00000358327
ENST00000369321
Show » Show » 388 43.7 No 0
CASP7-202 ENSP00000398107
ENST00000452490
P55210
Show all »
Show » Show » 278 31.6 No 0
CASP7-203 ENSP00000478285
ENST00000614447
P55210
Show all »
Show » Show » 253 28 No 0
CASP7-204 ENSP00000480584
ENST00000621345
P55210
Show all »
Show » Show » 303 34.3 No 0
CASP7-205 ENSP00000478999
ENST00000621607
P55210
Show all »
Show » Show » 336 37.8 No 0