KCNC2

GENERAL INFORMATION

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Gene name

KCNC2

Gene description

Potassium voltage-gated channel, Shaw-related subfamily, member 2

Protein class

FDA approved drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression in cerebral cortex. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 2 antibodies.
HPA019664 , CAB022571
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

KCNC2 (HGNC Symbol)

Synonyms

Kv3.2

Description

Potassium voltage-gated channel, Shaw-related subfamily, member 2 (HGNC Symbol)

Entrez gene summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

12

Cytoband

q21.1

Chromosome location (bp)

75040077 - 75209868

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166006 (version 78.38)

Entrez gene

3747

UniProt

Q96PR1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96PR1

Antibodypedia

KCNC2 antibodies


PROTEIN BROWSER

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ENST00000298972
 
ENST00000350228
 
ENST00000393288
 
ENST00000540018
 
ENST00000548513
 
ENST00000549446
 
ENST00000550433
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNC2-001 ENSP00000449253
ENST00000549446
Q96PR1
Show all »
Show » Show » 638 70.2 No 6
KCNC2-002 ENSP00000376966
ENST00000393288
Q96PR1
Show all »
Show » Show » 618 68.3 No 6
KCNC2-003 ENSP00000438423
ENST00000540018
Q96PR1
Show all »
Show » Show » 583 64.3 No 6
KCNC2-004 ENSP00000319877
ENST00000350228
Q96PR1
Show all »
Show » Show » 558 61.6 No 6
KCNC2-005 ENSP00000448301
ENST00000550433
Q96PR1
Show all »
Show » Show » 629 69.5 No 6
KCNC2-006 ENSP00000449941
ENST00000548513
Q96PR1
Show all »
Show » Show » 613 67.6 No 6
KCNC2-201 ENSP00000298972
ENST00000298972
Q96PR1
Show all »
Show » Show » 613 67.6 No 6