TK2

GENERAL INFORMATION

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Gene name

TK2

Gene description

Thymidine kinase 2, mitochondrial

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

15
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues showed weak to moderate cytoplasmic positivity withe a granular pattern. The small intestine, renal tubules, adrenal cortex and alveolar macrophages displayed strong staining. Lymphoid cells, glial cells, bile duct cells, renal glomeruli, squamous epithelium were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA041162
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

TK2

Synonyms

Description

Thymidine kinase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

This gene encodes a deoxyribonucleoside kinase that specifically phosphorylates thymidine, deoxycytidine, and deoxyuridine. The encoded enzyme localizes to the mitochondria and is required for mitochondrial DNA synthesis. Mutations in this gene are associated with a myopathic form of mitochondrial DNA depletion syndrome. Alternate splicing results in multiple transcript variants encoding distinct isoforms, some of which lack transit peptide, so are not localized to mitochondria. [provided by RefSeq, Dec 2012]

Chromosome

16

Cytoband

q21

Chromosome location (bp)

66508003 - 66552544

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166548 (version 78.38)

Entrez gene

7084

UniProt

O00142 (UniProt - Evidence at protein level)

neXtProt

NX_O00142

Antibodypedia

TK2 antibodies


PROTEIN BROWSER

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 « 
 
ENST00000299697
 
ENST00000417693
 
ENST00000451102
 
ENST00000525974
 
ENST00000527284
 
ENST00000527800
 
ENST00000544898
 
ENST00000545043
 
ENST00000561905
 
ENST00000562484
 
ENST00000563369
 
ENST00000563478
 
ENST00000564917
 
ENST00000569718
 
ENST00000620035
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TK2-001 ENSP00000414334
ENST00000451102
E5KNQ5
Show all »
Show » Show » 307 35.4 No 0
TK2-002 ENSP00000433770
ENST00000527800
O00142
Show all »
Show » Show » 168 20.3 No 0
TK2-003 ENSP00000434594
ENST00000525974
O00142
Show all »
Show » Show » 168 20.3 No 0
TK2-004 ENSP00000435312
ENST00000527284
O00142
Show all »
Show » Show » 234 27.6 No 0
TK2-005 ENSP00000407469
ENST00000417693
J3KS73
Show all »
Show » Show » 289 33.3 No 0
TK2-006 ENSP00000464313
ENST00000569718
Show » Show » 142 16.4 No 0
TK2-008 ENSP00000438143
ENST00000545043
O00142
Show all »
Show » Show » 240 28.4 No 0
TK2-009 ENSP00000463560
ENST00000563369
O00142
Show all »
Show » Show » 168 20.3 No 0
TK2-014 ENSP00000455187
ENST00000564917
H3BP77
Show all »
Show » Show » 282 32.9 No 0
TK2-016 ENSP00000462341
ENST00000563478
J3KS73
Show all »
Show » Show » 130 15.8 No 0
TK2-017 ENSP00000463326
ENST00000562484
J3QL12
Show all »
Show » Show » 89 10.7 No 0
TK2-019 ENSP00000462721
ENST00000561905
Show » 22 2.4 No 0
TK2-020 ENSP00000440898
ENST00000544898
O00142
Show all »
Show » Show » 265 31 No 0
TK2-201 ENSP00000299697
ENST00000299697
O00142
Show all »
Show » Show » 265 31 No 0
TK2-202 ENSP00000483833
ENST00000620035
O00142
Show all »
Show » Show » 247 28.9 No 0