ANPEP

GENERAL INFORMATION

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Gene name

ANPEP

Gene description

Alanyl (membrane) aminopeptidase

Protein class

CD markers
Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (duodenum, small intestine)
GTEx:Tissue enhanced (pancreas, small intestine)

Protein evidence

Evidence at protein level

Protein localization

Membranous and cytoplasmic expression in renal tubules, intestine, exocrine pancreas, prostate, liver and gall bladder.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004625 , CAB002417
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (duodenum, small intestine)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (pancreas, small intestine)

Organ

Expression



GENE INFORMATION

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Gene name

ANPEP (HGNC Symbol)

Synonyms

CD13, gp150, LAP1, p150, PEPN

Description

Alanyl (membrane) aminopeptidase (HGNC Symbol)

Entrez gene summary

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q26.1

Chromosome location (bp)

89784889 - 89815401

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166825 (version 78.38)

Entrez gene

290

UniProt

P15144 (UniProt - Evidence at protein level)

neXtProt

NX_P15144

Antibodypedia

ANPEP antibodies


PROTEIN BROWSER

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ENST00000300060
 
ENST00000559874
 
ENST00000560137
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANPEP-001 ENSP00000300060
ENST00000300060
P15144
Show all »
Show » Show » 967 109.5 No 1
ANPEP-002 ENSP00000452934
ENST00000559874
H0YKT6
Show all »
Show » Show » 103 11.1 No 1
ANPEP-003 ENSP00000453413
ENST00000560137
H0YM04
Show all »
Show » Show » 61 6.1 No 1