CRK

GENERAL INFORMATION

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Gene name

CRK

Gene description

V-crk avian sarcoma virus CT10 oncogene homolog

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Membranous and cytoplasmice xpression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
CAB010485
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CRK

Synonyms

Description

V-crk avian sarcoma virus CT10 oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

p13.3

Chromosome location (bp)

1420689 - 1463162

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167193 (version 78.38)

Entrez gene

1398

UniProt

P46108 (UniProt - Evidence at protein level)

neXtProt

NX_P46108

Antibodypedia

CRK antibodies


PROTEIN BROWSER

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ENST00000300574
 
ENST00000398970
 
ENST00000574295
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CRK-001 ENSP00000300574
ENST00000300574
P46108
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Show » Show » 304 33.8 No 0
CRK-002 ENSP00000381942
ENST00000398970
P46108
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Show » Show » 204 22.9 No 0
CRK-003 ENSP00000459505
ENST00000574295
I3L297
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Show » 223 25.5 No 0