KRT86

GENERAL INFORMATION

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Gene name

KRT86

Gene description

Keratin 86

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (bone marrow)
GTEx:Group enriched (skin)

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate to strong cytoplasmic and membranous positivity. Bile ducts, pancreatic islets, placental trophoblastic cells, smooth and skeletal muscle were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA039798
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (bone marrow)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (skin)

Organ

Expression



GENE INFORMATION

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Gene name

KRT86 (HGNC Symbol)

Synonyms

Hb6, KRTHB6, MNX

Description

Keratin 86 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

52249300 - 52309163

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170442 (version 78.38)

Entrez gene

3892

UniProt

O43790 (UniProt - Evidence at protein level)

neXtProt

NX_O43790

Antibodypedia

KRT86 antibodies


PROTEIN BROWSER

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ENST00000293525
 
ENST00000423955
 
ENST00000553310
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KRT86-001 ENSP00000444533
ENST00000423955
O43790
Show all »
Show » Show » 486 53.5 No 0
KRT86-002 ENSP00000452237
ENST00000553310
U3KPR1
Show all »
Show » Show » 143 15.4 No 0
KRT86-201 ENSP00000293525
ENST00000293525
O43790
Show all »
Show » Show » 486 53.5 No 0