CD14 protein expression summary - The Human Protein Atlas

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CD14

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and encoded protein(s) using information from HGNC and Ensembl, as well as predictions made as well as predictions made by the Human Protein Atlas project.
Protein	CD14 molecule
Gene nameⁱ Gene name according to HGNC.	CD14
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (blood, liver)
Subcellular locationⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.	Vesicles
Cancer prognostic summary	Prognostic marker in renal cancer (unfavourable)
Brain specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low human brain regional specificity
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (classical monocyte)
General main location (Predicted)ⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Coreceptor for bacterial lipopolysaccharide ref, ref. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) ref, ref. Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response ref. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway ref. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) ref.... show less
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Immunity, Inflammatory response, Innate immunity
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]... show less

TISSUE ATLASⁱ The Tissue Atlas contains information regarding the expression profiles of human genes both on the mRNA and protein level. The protein expression data from 44 normal human tissue types is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Group enriched (blood, liver)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Selective expression in subsets of immune cells.

BRAIN ATLASⁱ The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is here available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	Localized to the Vesicles
Cell line specificityⁱ The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all NX values in all analyzed cell lines. Read more	Cell line enhanced (A549, CACO-2, SiHa)

BLOOD ATLASⁱ The Blood Atlas contains single cell type information on genome-wide RNA expression profiles of human protein-coding genes covering various B- and T-cells, monocytes, granulocytes and dendritic cells. In addition, an analysis of the human secretome is presented. including annotation of the genes predicted to be actively secreted to human blood. An analysis of the proteins detected in human blood is also presented. Read more

Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. A gene will only have one location and the categories and their hierarchy is: Intracellular and membrane Secreted to blood Secreted in brain Secreted to digestive system Secreted in female reproductive system Secreted in male reproductive system Secreted to extracellular matrix Secreted in other tissues Secreted - unknown location Read more	Secreted to blood
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (classical monocyte)
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	Yes
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes

PATHOLOGY ATLASⁱ

Renal cancer p<0.001

Prognostic summary	Prognostic marker in renal cancer (unfavourable)
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CD14
Synonyms
Description	CD14 molecule (HGNC Symbol)
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140631728 - 140633701
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	5
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Protein class(es) of the gene product according to selected gene lists. List of protein classes.	Cancer-related genes CD markers Plasma proteins
Ensembl	ENSG00000170458 (version 92.38)
Entrez gene	929
UniProt	P08571 (UniProt - Evidence at protein level)
neXtProt	NX_P08571
Antibodypedia	CD14 antibodies

PROTEIN BROWSERⁱ

CD14-201

CD14-202

CD14-203

CD14-204

CD14-205

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD14-201 ENSP00000304236 ENST00000302014	P08571 [Direct mapping] Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001530 [lipopolysaccharide binding] GO:0001847 [opsonin receptor activity] GO:0002224 [toll-like receptor signaling pathway] GO:0002237 [response to molecule of bacterial origin] GO:0002376 [immune system process] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0009408 [response to heat] GO:0009617 [response to bacterium] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016019 [peptidoglycan receptor activity] GO:0016020 [membrane] GO:0030667 [secretory granule membrane] GO:0031225 [anchored component of membrane] GO:0031362 [anchored component of external side of plasma membrane] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032026 [response to magnesium ion] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032729 [positive regulation of interferon-gamma production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034128 [negative regulation of MyD88-independent toll-like receptor signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034612 [response to tumor necrosis factor] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043312 [neutrophil degranulation] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045471 [response to ethanol] GO:0045807 [positive regulation of endocytosis] GO:0046696 [lipopolysaccharide receptor complex] GO:0050715 [positive regulation of cytokine secretion] GO:0051602 [response to electrical stimulus] GO:0070062 [extracellular exosome] GO:0070266 [necroptotic process] GO:0070891 [lipoteichoic acid binding] GO:0071219 [cellular response to molecule of bacterial origin] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071723 [lipopeptide binding] GO:0071726 [cellular response to diacyl bacterial lipopeptide] GO:0071727 [cellular response to triacyl bacterial lipopeptide] GO:0097190 [apoptotic signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	375 aa 40.1 kDa	Yes	0
CD14-202 ENSP00000385519 ENST00000401743	P08571 [Direct mapping] Monocyte differentiation antigen CD14 Monocyte differentiation antigen CD14, urinary form Monocyte differentiation antigen CD14, membrane-bound form Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001530 [lipopolysaccharide binding] GO:0001847 [opsonin receptor activity] GO:0002224 [toll-like receptor signaling pathway] GO:0002376 [immune system process] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0010008 [endosome membrane] GO:0016019 [peptidoglycan receptor activity] GO:0016020 [membrane] GO:0030667 [secretory granule membrane] GO:0031225 [anchored component of membrane] GO:0031362 [anchored component of external side of plasma membrane] GO:0032729 [positive regulation of interferon-gamma production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0034128 [negative regulation of MyD88-independent toll-like receptor signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043312 [neutrophil degranulation] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0046696 [lipopolysaccharide receptor complex] GO:0070062 [extracellular exosome] GO:0070266 [necroptotic process] GO:0070891 [lipoteichoic acid binding] GO:0071219 [cellular response to molecule of bacterial origin] GO:0071222 [cellular response to lipopolysaccharide] GO:0071223 [cellular response to lipoteichoic acid] GO:0071723 [lipopeptide binding] GO:0071726 [cellular response to diacyl bacterial lipopeptide] GO:0071727 [cellular response to triacyl bacterial lipopeptide] GO:0097190 [apoptotic signaling pathway] GO:1901224 [positive regulation of NIK/NF-kappaB signaling] GO:2000484 [positive regulation of interleukin-8 secretion] Show all	375 aa 40.1 kDa	Yes	0
CD14-203 ENSP00000426543 ENST00000498971	D6RFL4 [Direct mapping] Monocyte differentiation antigen CD14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		213 aa 23.3 kDa	Yes	0
CD14-204 ENSP00000425447 ENST00000512545	D6RD81 [Direct mapping] Monocyte differentiation antigen CD14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		55 aa 6.2 kDa	Yes	0
CD14-205 ENSP00000430884 ENST00000519715	E7EVL5 [Direct mapping] Monocyte differentiation antigen CD14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		81 aa 9 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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