GRIK1

GENERAL INFORMATION

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Gene name

GRIK1

Gene description

Glutamate receptor, ionotropic, kainate 1

Protein class

FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 1 antibody.
HPA014623
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (adrenal gland, cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

GRIK1 (HGNC Symbol)

Synonyms

GluK1, GLUR5

Description

Glutamate receptor, ionotropic, kainate 1 (HGNC Symbol)

Entrez gene summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q21.3

Chromosome location (bp)

29536933 - 29940033

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171189 (version 78.38)

Entrez gene

2897

UniProt

P39086 (UniProt - Evidence at protein level)

neXtProt

NX_P39086

Antibodypedia

GRIK1 antibodies


PROTEIN BROWSER

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ENST00000309434
 
ENST00000327783
 
ENST00000389124
 
ENST00000389125
 
ENST00000399907
 
ENST00000399909
 
ENST00000399913
 
ENST00000399914
 
ENST00000535441
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRIK1-001 ENSP00000373777
ENST00000389125
P39086
Show all »
Show » Show » 905 102.6 No 3
GRIK1-002 ENSP00000382791
ENST00000399907
P39086
Show all »
Show » Show » 918 104 No 3
GRIK1-003 ENSP00000382798
ENST00000399914
E7EPY9
Show all »
Show » Show » 934 106.2 No 3
GRIK1-004 ENSP00000327687
ENST00000327783
E7ENK3
Show all »
Show » Show » 949 107.9 No 3
GRIK1-005 ENSP00000373776
ENST00000389124
H7BYG7
Show all »
Show » Show » 871 98.8 No 3
GRIK1-006 ENSP00000382797
ENST00000399913
E9PD61
Show all »
Show » Show » 920 104.4 No 3
GRIK1-008 ENSP00000382793
ENST00000399909
E7EPZ0
Show all »
Show » Show » 903 102.3 No 3
GRIK1-201 ENSP00000311646
ENST00000309434
Q71UA3
Show all »
Show » Show » 879 99.5 No 3
GRIK1-202 ENSP00000446326
ENST00000535441
D3DSE2
Show all »
Show » Show » 866 98.1 No 3