BPTF

GENERAL INFORMATION

? »

Gene name

BPTF

Gene description

Bromodomain PHD finger transcription factor

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Strong cytoplasmic positivity was seen in Paneth cells of intestinal tract, respiratory epithelia, gall bladder, subsets of cells in seminiferous ducts and adrenal cortex. Salivary ductal cells, hepatocytes, placental trophoblasts, thyroid, neuronal cells of CNS were moderately stained. Remaining normal tissues were negative or weakly stained.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA029069
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

BPTF (HGNC Symbol)

Synonyms

FAC1, FALZ, NURF301

Description

Bromodomain PHD finger transcription factor (HGNC Symbol)

Entrez gene summary

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q24.2

Chromosome location (bp)

67825524 - 67984378

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000171634 (version 78.38)

Entrez gene

2186

UniProt

Q12830 (UniProt - Evidence at protein level)

neXtProt

NX_Q12830

Antibodypedia

BPTF antibodies


PROTEIN BROWSER

? »
 
 
 « 
 
ENST00000306378
 
ENST00000321892
 
ENST00000335221
 
ENST00000342579
 
ENST00000424123
 
ENST00000544491
 
ENST00000544778
 
ENST00000577837
 
ENST00000580465
 
ENST00000581258
 
ENST00000582467
 
ENST00000583990
 
 » 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BPTF-001 ENSP00000388405
ENST00000424123
E7ETD6
Show all »
Show » Show » 2764 308.1 No 0
BPTF-002 ENSP00000307208
ENST00000306378
Q12830
Show all »
Show » Show » 2920 325.1 No 0
BPTF-004 ENSP00000463845
ENST00000581258
Show » Show » 420 48.3 No 0
BPTF-005 ENSP00000462535
ENST00000580465
Show » Show » 484 52.5 No 0
BPTF-006 ENSP00000343837
ENST00000342579
Q86TN2
Show all »
Show » Show » 650 72.5 No 0
BPTF-009 ENSP00000440854
ENST00000544778
F5GXF5
Show all »
Show » Show » 2457 271.5 No 0
BPTF-010 ENSP00000463776
ENST00000582467
Show » 339 35.7 No 0
BPTF-011 ENSP00000443949
ENST00000544491
Show » 137 14.7 No 0
BPTF-017 ENSP00000463736
ENST00000583990
Show » Show » 69 7.8 No 0
BPTF-018 ENSP00000462703
ENST00000577837
Show » Show » 64 7.6 No 0
BPTF-201 ENSP00000315454
ENST00000321892
Q12830
Show all »
Show » Show » 3046 338.3 No 0
BPTF-202 ENSP00000334351
ENST00000335221
Show » Show » 810 91.9 No 0