ADRA1D

GENERAL INFORMATION

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Gene name

ADRA1D

Gene description

Adrenoceptor alpha 1D

Protein class

FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (prostate)
GTEx:Mixed

Protein evidence

Evidence at transcript level

Protein localization

Strong cytoplasmic positivity was observed in renal tubules. Lung macrophages, duodenum, adrenal cortex, heart and skeletal myocytes showed moderate cytoplasmic staining. Moderate cytoplasmic and nuclear positivity was observed in the liver. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA038789
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (prostate)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ADRA1D (HGNC Symbol)

Synonyms

ADRA1, ADRA1A, ADRA1R

Description

Adrenoceptor alpha 1D (HGNC Symbol)

Entrez gene summary

Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008]

Chromosome

20

Cytoband

p13

Chromosome location (bp)

4220631 - 4249074

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000171873 (version 78.38)

Entrez gene

146

UniProt

P25100 (UniProt - Evidence at transcript level)

neXtProt

NX_P25100

Antibodypedia

ADRA1D antibodies


PROTEIN BROWSER

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ENST00000379453
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRA1D-001 ENSP00000368766
ENST00000379453
P25100
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