The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Distinct membranous staining was observed in gall bladder, endometrial glands, the intestine, renal glomeruli and fractions of renal tubules. Sertoli cells, melanocytes, astrocytes and endothelium displayed moderate to strong cytoplasmic immunoreactivity. Remaining normal cells were weakly stained or negative.
Moderate to strong membranous positivity was observed in a majority of normal tissues. Blood vessels were distinctly stained. Glandular cells in female reproductive organs, glial cells, immune cells and fibroblasts were negative.
Glomeruli, Purkinje cells and gall bladder displayed strong cytoplasmic staining. Moderate cytoplasmic and membranous positivity was observed in glandular cells of cervix, heart muscle cells, neuronal cells of lateral ventricle, trophoblastic cells, intestine and stomach. Remaining normal tissues were weakly stained or negative.
Glomeruli, endothelial cells and skeletal muscle cells displayed strong cytoplasmic immunoreactivity. Placental trophoblasts showed strong cytoplasmic and membranous staining. Gall bladder, neuropil in cerebral cortex and basal layer keratinocytes in skin were moderately stained. Remaining normal cells were negative.