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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
q13.3
Chromosome location (bp)
57516588 - 57521737
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Multifunctional transcription factor in endoplasmic reticulum (ER) stress response 1,2,3. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress 4,5. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (By similarity). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L 6,7,8,9. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) 10,11,12. Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity 13. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P35638 [Direct mapping] DNA damage-inducible transcript 3 protein
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Q53YD1 [Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001955[blood vessel maturation] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005770[late endosome] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006983[ER overload response] GO:0006986[response to unfolded protein] GO:0007049[cell cycle] GO:0007605[sensory perception of sound] GO:0008140[cAMP response element binding protein binding] GO:0009611[response to wounding] GO:0009948[anterior/posterior axis specification] GO:0010467[gene expression] GO:0010506[regulation of autophagy] GO:0016055[Wnt signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032713[negative regulation of interleukin-4 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032792[negative regulation of CREB transcription factor activity] GO:0032993[protein-DNA complex] GO:0034976[response to endoplasmic reticulum stress] GO:0036119[response to platelet-derived growth factor] GO:0036488[CHOP-C/EBP complex] GO:0036499[PERK-mediated unfolded protein response] GO:0036500[ATF6-mediated unfolded protein response] GO:0042594[response to starvation] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043522[leucine zipper domain binding] GO:0043525[positive regulation of neuron apoptotic process] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0045454[cell redox homeostasis] GO:0045599[negative regulation of fat cell differentiation] GO:0045662[negative regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051209[release of sequestered calcium ion into cytosol] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0060840[artery development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0072655[establishment of protein localization to mitochondrion] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:0140467[integrated stress response signaling] GO:1901216[positive regulation of neuron death] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1904738[vascular associated smooth muscle cell migration] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990442[intrinsic apoptotic signaling pathway in response to nitrosative stress] GO:1990617[CHOP-ATF4 complex] GO:1990622[CHOP-ATF3 complex] GO:1990874[vascular associated smooth muscle cell proliferation] GO:2000016[negative regulation of determination of dorsal identity] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
P35638 [Direct mapping] DNA damage-inducible transcript 3 protein
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Q53YD1 [Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006983[ER overload response] GO:0006986[response to unfolded protein] GO:0007049[cell cycle] GO:0008140[cAMP response element binding protein binding] GO:0009948[anterior/posterior axis specification] GO:0010506[regulation of autophagy] GO:0016055[Wnt signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032713[negative regulation of interleukin-4 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032792[negative regulation of CREB transcription factor activity] GO:0032993[protein-DNA complex] GO:0034976[response to endoplasmic reticulum stress] GO:0036488[CHOP-C/EBP complex] GO:0036499[PERK-mediated unfolded protein response] GO:0036500[ATF6-mediated unfolded protein response] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043522[leucine zipper domain binding] GO:0043525[positive regulation of neuron apoptotic process] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0045454[cell redox homeostasis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:0140467[integrated stress response signaling] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990617[CHOP-ATF4 complex] GO:1990622[CHOP-ATF3 complex] GO:2000016[negative regulation of determination of dorsal identity] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
F8W133 [Direct mapping] DDIT3 upstream open reading frame protein
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Cancers Cancers of soft tissues and bone
P35638 [Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006983[ER overload response] GO:0006986[response to unfolded protein] GO:0007049[cell cycle] GO:0008140[cAMP response element binding protein binding] GO:0009948[anterior/posterior axis specification] GO:0010506[regulation of autophagy] GO:0016055[Wnt signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032713[negative regulation of interleukin-4 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032792[negative regulation of CREB transcription factor activity] GO:0032993[protein-DNA complex] GO:0034976[response to endoplasmic reticulum stress] GO:0036488[CHOP-C/EBP complex] GO:0036499[PERK-mediated unfolded protein response] GO:0036500[ATF6-mediated unfolded protein response] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043522[leucine zipper domain binding] GO:0043525[positive regulation of neuron apoptotic process] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0045454[cell redox homeostasis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:0140467[integrated stress response signaling] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990617[CHOP-ATF4 complex] GO:1990622[CHOP-ATF3 complex] GO:2000016[negative regulation of determination of dorsal identity] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
P35638 [Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006983[ER overload response] GO:0006986[response to unfolded protein] GO:0007049[cell cycle] GO:0008140[cAMP response element binding protein binding] GO:0009948[anterior/posterior axis specification] GO:0010506[regulation of autophagy] GO:0016055[Wnt signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032713[negative regulation of interleukin-4 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032792[negative regulation of CREB transcription factor activity] GO:0032993[protein-DNA complex] GO:0034976[response to endoplasmic reticulum stress] GO:0036488[CHOP-C/EBP complex] GO:0036499[PERK-mediated unfolded protein response] GO:0036500[ATF6-mediated unfolded protein response] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043522[leucine zipper domain binding] GO:0043525[positive regulation of neuron apoptotic process] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0045454[cell redox homeostasis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:0140467[integrated stress response signaling] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990617[CHOP-ATF4 complex] GO:1990622[CHOP-ATF3 complex] GO:2000016[negative regulation of determination of dorsal identity] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]
P35638 [Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Q53YD1 [Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of soft tissues and bone Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0006983[ER overload response] GO:0006986[response to unfolded protein] GO:0007049[cell cycle] GO:0008140[cAMP response element binding protein binding] GO:0009948[anterior/posterior axis specification] GO:0010506[regulation of autophagy] GO:0016055[Wnt signaling pathway] GO:0030968[endoplasmic reticulum unfolded protein response] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032689[negative regulation of interferon-gamma production] GO:0032700[negative regulation of interleukin-17 production] GO:0032713[negative regulation of interleukin-4 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032792[negative regulation of CREB transcription factor activity] GO:0032993[protein-DNA complex] GO:0034976[response to endoplasmic reticulum stress] GO:0036488[CHOP-C/EBP complex] GO:0036499[PERK-mediated unfolded protein response] GO:0036500[ATF6-mediated unfolded protein response] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043161[proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043522[leucine zipper domain binding] GO:0043525[positive regulation of neuron apoptotic process] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0045454[cell redox homeostasis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051726[regulation of cell cycle] GO:0051898[negative regulation of protein kinase B signaling] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0090090[negative regulation of canonical Wnt signaling pathway] GO:0090575[RNA polymerase II transcription regulator complex] GO:0120163[negative regulation of cold-induced thermogenesis] GO:0140416[transcription regulator inhibitor activity] GO:0140467[integrated stress response signaling] GO:1902237[positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903026[negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990617[CHOP-ATF4 complex] GO:1990622[CHOP-ATF3 complex] GO:2000016[negative regulation of determination of dorsal identity] GO:2001244[positive regulation of intrinsic apoptotic signaling pathway]