SMAD2

GENERAL INFORMATION

? »

Gene name

SMAD2

Gene description

SMAD family member 2

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transcription factors

Predicted localization

Intracellular,Membrane

Number of transcripts

10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most normal tissues displayed moderate nuclear positivity. Strong nuclear staining was observed in decidual cells, breast, most cells in CNS and male genitalia. Hepatocytes and lymphoid tissues were weakly stained.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB025507
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

SMAD2 (HGNC Symbol)

Synonyms

JV18-1, MADH2, MADR2

Description

SMAD family member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

Chromosome

18

Cytoband

q21.1

Chromosome location (bp)

47808957 - 47931146

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175387 (version 78.38)

Entrez gene

4087

UniProt

Q15796 (UniProt - Evidence at protein level)

neXtProt

NX_Q15796

Antibodypedia

SMAD2 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000262160
 
ENST00000356825
 
ENST00000402690
 
ENST00000585978
 
ENST00000586040
 
ENST00000586514
 
ENST00000587269
 
ENST00000587421
 
ENST00000589877
 
ENST00000591214
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SMAD2-001 ENSP00000262160
ENST00000262160
Q15796
Show all »
Show » Show » 467 52.3 No 0
SMAD2-002 ENSP00000384449
ENST00000402690
Q15796
Show all »
Show » Show » 467 52.3 No 0
SMAD2-003 ENSP00000467075
ENST00000591214
B7Z5N5
Show all »
Show » Show » 431 48.7 No 1
SMAD2-004 ENSP00000466193
ENST00000586040
Q15796
Show all »
Show » Show » 437 49 No 0
SMAD2-005 ENSP00000465355
ENST00000586514
K7EJX0
Show all »
Show » Show » 217 24.5 No 0
SMAD2-006 ENSP00000465971
ENST00000589877
K7EL92
Show all »
Show » Show » 109 11.9 No 0
SMAD2-007 ENSP00000468202
ENST00000587421
K7ERC7
Show all »
Show » Show » 137 15.2 No 0
SMAD2-008 ENSP00000466254
ENST00000587269
K7EJX0
Show all »
Show » Show » 217 24.5 No 0
SMAD2-009 ENSP00000468732
ENST00000585978
K7ESI8
Show all »
Show » Show » 108 11.7 No 0
SMAD2-201 ENSP00000349282
ENST00000356825
Q15796
Show all »
Show » Show » 437 49 No 0