ERCC4

GENERAL INFORMATION

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Gene name

ERCC4

Gene description

Excision repair cross-complementation group 4

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in a majority of the tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
CAB000156
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ERCC4 (HGNC Symbol)

Synonyms

FANCQ, RAD1, XPF

Description

Excision repair cross-complementation group 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5' incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]

Chromosome

16

Cytoband

p13.12

Chromosome location (bp)

13920157 - 13952345

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175595 (version 78.38)

Entrez gene

2072

UniProt

Q92889 (UniProt - Evidence at protein level)

neXtProt

NX_Q92889

Antibodypedia

ERCC4 antibodies


PROTEIN BROWSER

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ENST00000311895
 
ENST00000575156
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERCC4-001 ENSP00000310520
ENST00000311895
Q92889
Show all »
Show » Show » 916 104.5 No 0
ERCC4-003 ENSP00000459933
ENST00000575156
Q92889
Show all »
Show » Show » 372 42.7 No 0